San Francisco 49ers inactives and starters, Week 18

Brock Purdy is projected to start at quarterback for the San Francisco 49ers at the Arizona Cardinals in Week 18. Mac Jones is listed second. Kickoff is Sun, Jan 10, 12:00 AM ET.

Full 2026 NFL schedule

• Nick MartinLBInjured ReserveThe 49ers placed Martin (hamstring) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports.
• Nate HobbsCBInjured ReserveThe 49ers placed Hobbs (groin) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports.
• Brayden WillisTEQuestionableWillis (concussion) participated in Tuesday's practice, Nick Wagoner of ESPN.com reports.
• Christian McCaffreyRBQuestionableMcCaffrey (undisclosed) suited up and went through drills at Tuesday's practice, according to Matt Lively of CBS Sports Bay Area.
• Kyle JuszczykFBQuestionableJuszczyk (finger) is not practicing Tuesday, Matt Barrows of The Athletic reports.
• Nick BosaDEQuestionableBosa (knee) worked to the side on the practice field Monday and is expected to do the same Tuesday, with a return to practice planned for Wednesday, Matt Maiocco of NBC Sports Bay Area reports.
• Mike EvansWRQuestionable49ers general manager John Lynch said Tuesday the team hopes to have Evans (groin) back at practice next week, David Lombardi of the San Francisco Standard reports.
• Nick ZakeljOTInjured ReserveZakelj (undisclosed) was placed on the 49ers' injured reserve Sunday.
• Brett TothCInjured ReserveThe 49ers placed Toth (concussion) on injured reserve Sunday.
• Austen PleasantsOTInjured ReserveThe 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday.
• George KittleTEQuestionableKittle (Achilles) will be eased back into practice this week, Matt Barrows of The Athletic reports.
• Mykel WilliamsDEOutWilliams (knee) was moved to the reserve/PUP list by the 49ers on Sunday.
• Christian KirkWRInjured ReserveKirk (calf) was placed on injured reserve by the 49ers on Sunday with a designation to return.
• Isaac GuerendoRBOutGuerendo (pectoral) was placed on the reserve/PUP list Sunday, Jeremy Fowler of ESPN reports.
• Ephesians PrysockCBQuestionablePrysock suffered a shoulder injury and will not return to Thursday's preseason matchup with the Raiders, Noah Furtado of the San Francisco Chronicle reports.
• Victor DimukejeDEInjured ReserveDimukeje (undisclosed) was placed on injured reserve by the 49ers on Thursday.
• De'Zhaun StriblingWRQuestionableStribling (shoulder) won't suit up for Thursday's preseason contest at Las Vegas, David Lombardi of SFStandard.com reports.

Per ESPN's public injury report, as of Sep 1, 11:58 PM ET.

Who is starting for the 49ers in Week 18?

Brock Purdy is projected to start at quarterback for the San Francisco 49ers at the Arizona Cardinals in Week 18. Mac Jones is listed second. Kickoff is Sun, Jan 10, 12:00 AM ET.

Are the 49ers playing in Week 18?

Yes. Brock Purdy is projected to start at quarterback for the San Francisco 49ers at the Arizona Cardinals in Week 18. Mac Jones is listed second. Kickoff is Sun, Jan 10, 12:00 AM ET.

Where do the 49ers's Week 18 inactives and injury designations come from?

Injury and inactive designations shown here are pulled verbatim from ESPN's public injury report, last fetched Sep 1, 10:58 PM CDT (17 players listed).